Cognitive Impairment and Dementia in Parkinson's Disease

Bìa trước
OUP Oxford, 7 thg 1, 2010 - 284 trang
Parkinson's disease has long been perceived as a pure motor disorder, partly due to its initial description by James Parkinson, who suggested that "senses and intellect remain intact", and partly due to the fact that patients with PD did not survive long, before effective treatment became available. As the survival time of patients with Parkinson's disease has substantially increased due to modern treatment, it has become apparent that cognitive deficits and dementia are also frequent features, especially in elderly patients. With the progression of the disease and age, dementia develops in a substantial number of patients and constitutes a major therapeutic challenge. Dementia has thus increasingly been the focus of research and practice in recent years and a large body of knowledge has been accumulated. Despite these developments there has been no single volume dedicated to this topic. This book provides an extensive overview of the current status of knowledge pertaining to cognitive impairment and dementia associated with Parkinson's disease, intended as a reference book for general neurologists, neurology residents and also those with a special interest in movement disorders. In this edited volume experts in the field describe in detail all aspects of cognitive impairment and dementia in Parkinson's disease, including epidemiology, spectrum of clinical features, pathology, neurochemistry and genetics, findings in auxiliary investigations, relation to other neurodegenerative disorders, diagnostic process and management, and rounded up by discussion of future research directions and expectations. The text is complemented and enriched with tables, figures and heavily referenced to encompass all relevant literature.
 

Các trang được chọn

Nội dung

1 Introduction
1
2 Epidemiology of dementia associated with Parkinsons disease
5
3 General features mode of onset and course of dementia in Parkinsons disease
15
4 Cognitive profile in Parkinsons disease dementia
27
5 Neuropsychiatric symptoms in Parkinsons disease dementia
45
6 Interaction between affect and executive functions in Parkinsons disease
65
7 Motor symptoms and phenotype in patients with Parkinsons disease dementia
75
8 Interaction between cognition and gait in patients with Parkinsons disease
87
12 Genetic basis of dementia in Parkinsons disease
141
13 Neurochemical pathology of Parkinsons disease dementia
153
14 Pathological correlates of dementia in Parkinsons disease
171
15 Cognitive impairment in nondemented patients with Parkinsons disease
179
relationship of Parkinsons disease dementia to dementia with Lewy bodies
199
17 Spectrum of disorders with parkinsonism and dementia
215
18 Diagnosis of dementia in Parkinsons disease
231
19 Management of Parkinsons disease dementia and dementia with Lewy bodies
245

9 Disorders of sleep and autonomic function in Parkinsons disease dementia
101
10 Neuroimaging in patients with Parkinsons disease dementia
115
11 Electrophysiological and other auxiliary investigations in patients with Parkinsons disease dementia
129
what will the future bring?
257
Index
263
Bản quyền

Ấn bản in khác - Xem tất cả

Thuật ngữ và cụm từ thông dụng

Giới thiệu về tác giả (2010)

Professor Murat Emre was born in 1956 in Eregli, Turkey. After studying medicine at the Istanbul Faculty of Medicine he trained in Neuroscience and Clinical Neurology at the University of Zürich. He then worked in the fields of neurorehabilitation and clinical research in Switzerland for several years. He trained in movement disorders with Prof. David Marsden at the Queen Square National Hospital for Nervous Diseases, London and in behavioral neurology with Prof. Marsel Mesulam at the Beth Israel Hospital and Harvard Medical School. In 1996 he was appointed as Professor of Neurology at the Istanbul Faculty of Medicine where he started the Behavioral Neurology and Movement Disorders Unit, which he has been chairing since then. His research interests are in Parkinson's disease and related disorders, in particular cognitive aspects of the disease, Alzheimer's disease and related dementias.

Thông tin thư mục