Protein Structure: Determination, Analysis, and Applications for Drug DiscoveryDaniel Chasman CRC Press, 18 thg 3, 2003 - 576 trang This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational met |
Nội dung
Structural Biology and Structural Genomics A Federal Agency Perspective | 1 |
Producing Proteins | 9 |
Crystallization of Membrane Proteins | 27 |
Prospects for HighThroughput Structure Determination by XRay Crystallography | 55 |
Prospects for HighThroughput Structure Determination of Proteins by NMR Spectroscopy | 95 |
Automated Molecular Replacement | 141 |
Comparative Protein Structure Modeling | 167 |
Rising Accuracy of Protein Secondary Structure Prediction | 207 |
Automated Genome Functional Annotation for Structural Genomics | 349 |
The Importance of StructureBased Function Annotation to Drug Discovery | 369 |
The Protein Data Bank | 389 |
The European Bioinformatics Institute Macromolecular Structure Database EMSD | 407 |
Molecular Docking in StructureBased Design | 417 |
Use of Pharmacophores in StructureBased Drug Design | 453 |
The Structure of Human lnterferon𝛃1a Avonex and its Relation to Activity A Case Study of the Use of Structural Data in the Arena of Protein Pharm... | 483 |
GProteinCoupled Receptors Diverse Functions and Shared Mechanisms of Action Interpreted Through the Structure of Rhodopsin | 521 |
Novel Fold and Ab Initio Methods for Protein Structure Generation | 251 |
Identifying Errors in ThreeDimensional Protein Models | 277 |
Comparative Analysis and Evolutionary Classification of Protein Structures | 315 |
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Thuật ngữ và cụm từ thông dụng
Acad Sci USA accuracy active algorithm amino acid analysis annotation approach assignment atoms automated backbone binding Biochem biological calculated cell Chem coli comparative modeling complex Comput conformation conserved crystal structure crystallography cytokine database detergent docking domain drug effects on function errors evaluation experimental gene genetic GPCRs helices helix high-throughput homologous homology modeling hydrogen bond hydrophobic identify IFN-ẞ IFNAR2 inhibitors interactions interferon ligand loop membrane proteins methods micelles Mol Biol molecular molecular docking molecules motifs mutations Natl Acad Sci NOES nsSNPs Nucleic Acids optimization peptide pharmacophore phase polymorphisms potential Proc Natl Acad protein folding protein sequence protein structure prediction receptor regions residual dipolar couplings residues rhodopsin rmsd Sali sample screening secondary structure prediction segments sequence alignment sequence identity side chains similarity solution Struct Biol structural genomics structure determination structure-based SWISS-PROT target three-dimensional tion transducin X-ray X-ray crystallography